Scott,
What are your desktop speakers plugged in to?
My guess is the speakers only have a mini-jack and it's probably still plugged in to the old soundcard. Is that the case?
I've got a Delta Dio 2496 and I had the same problem because the card doesn't have a mini-jack input for my desktop speakers. I went to radio shack and bought a mini-jack > RCA adapter so that I can plug my speakers into the analog out on the 2496. That might be what you need to do.
Your speakers have to be plugged into the Audiophile if you want to listen to the music that is going into that card. At least, that's my understanding.