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REAPER: http://www.reaper.fm/index.phpBest $60 I ever spent. I use Izotope Ozone all the time with Reaper and it works great. There's some good basic plugins that come with it also.
Big problem with Audition and VST...there's no delay compensation. So when mixing in AA and you throw on some Ozone plug-ins, it'll go out of sync when monitoring. It'll line up when exporting, but still very annoying and a deal breaker for heavy mixing.
I've used AA3, AA6, and AA-CC. None of them utilized VST delay compensation, so not sure! In any case, I don't use Audition for mixing, much prefer Nuendo as a multitrack. Audition is better for wave editing, time alignment, etc.