I've been running 24/44.1 for the past month and loving it. I don't really have a 24-bit playback option, but in the future if I do, I save all of my originals/masters. I've been running at 24-bit mostly for the extra headroom, which is nice to have. On the sampling front, I personally can't really tell the difference, so I like not having to resample in my workflow. However, if I know I am going to sync to MiniDV or encode DV video to DVD, I'll usually record at 48 because that's what DV/DVD runs it's PCM at typically. Anyway, my main point is that you may want to run at 24-bit for two main reasons: (1) headroom, and (2) archiving for possible future use. That's my two cents...