one issue that's worth mentioning. If you're planning on using the card's analog outs (as opposed to digital outs), the inside of a computer is chock-full of electromagnetic interference and is therefore not a good environment for analog signals (i.e. you'll pick up noise).
Have you ever put it on a spectrum analyser to see how much noise actually comes through?
I keep meaning to do this and haven't, but to my ears there's little or no noise compared to the external DAC with the Juli@.
I did have a time with an ESI driver conflict, but resolved it by uninstalling Norton Systemworks.
I also find the Juli@ pops on power-up, something I have always despised in any audio device.
I don't power the monitors until the PC is up to avoid the pop.
As far as EMI noise, the use of correct-sized ferrite on the analog outs/ins will help a great deal, as will proper grounding technique.
Side note:
My current ground-loop problem turned out to be from the cable wire into the box into my tv and back to my DVD player!
Once I used an isolation transformer on the cable wire, evertything quieted down enormously.