Well as Eigenklang mentioned, I think for normal purposes the 'things of life', like furniture, bookcases, shelving, pictures, lamps, busts of Beethoven and the like make for good irregularity that provides diffusion. Those things can mostly fill the roll of the non-parallel walls in fancy purpose-built rooms.
Most people suggest a not-irregular, symmetrical arrangement of the speakers and listening position.
A rectangular room is a good basic, normal room shape for sound. Some people like the idea of using the golden-ratio to determine the wall dimensions.. like the Parthenon. You have to admit the Greeks had some advanced acoustics going on with those amphitheaters. As for the how the Parthenon sounds?...