Outdoors so far is the only place I've really considered not runnning the low cut since I started using it, and that has only been two shows. One was Ratdog and one was Phil Lesh.
I was thinking about not running it for the Bob show, but ended up not making the decision one way or another. My partner decided she wanted to go to the show, something I generally don't encourage, lol, and argghh, of course I was waiting on her at the bathroom when the show started. Luckily I was taping with another guy and he started my deck rolling, and the low cut was enabled in my default config, so I just ran with it. I don't think it hurt to have it on at all.
Phil even outdoors definitely benefitted from a little low cut.
Pretty much everything else I have taped since I started using it has been either pretty loud, in a boomy room or both.