According to the Izotope site
System requirements
Operating Systems
Mac: macOS Catalina (10.15.7) – macOS Monterey (12.5.x)
Win: Windows 10 – Windows 11
Plugin Formats
AU, AAX, AAX Audiosuite, VST3, AU ARA (Spectral Editor ARA & Music Rebalance ARA)*.
* All plug-in formats are 64-bit only. VST2 is no longer supported.
RX 10 AU ARA plug-ins are compatible with Logic Pro only.
RX 10 Ambience Match, Dialogue Isolate, and De-rustle plug-ins are available as AAX Audiosuite plug-ins in Pro Tools only.
Supported Hosts
Logic Pro 10.6.3 - 10.7.x, Pro Tools 2021 - 2022, Ableton Live 11, Cubase 11 - 12, Nuendo 12, Studio One 5, Reaper 6, FL Studio 20, Audition CC 2022, Premiere Pro CC 2022
RX 10 Audio Editor Plug-in Hosting
AU and VST2 plug-ins can be hosted in the RX Audio Editor
Note: VST2 plug-in hosting will be deprecated and replaced with VST3 plug-in hosting in a future RX 10 patch