Topic: Anyone ever run a RME ADI2 A/D converter

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my buddy just added this machine to our collection and we have run it a couple of time with a variety of pre's (V2, M248, MixPre, & Sonosax).  My question is to anyone who has had experience with this machine. What setting do you use for input and output? Options are Low Gain, +4 or -10.  So far, levels have been unpredictable and all over the place at opening of shows.  Anyway, any help would be appreciated.  Thanks
BP