If I have the choice, I'll use my friend's DR-680 to handle the multiple sources. This will make synching the recording extremely easy once I've lined up beats and checked them at varying points throughout the recording.
However, there have been times where I've had to use an M10 or two M10's and the DR-680 to record a show. I've then had to reclock one source against another. If it's done with extreme care (and precise measurements) you can get the files to match within hundredths of a second in a 2-and-a-half hour show. Most recently, I had a show where I had a soundboard feed, AKG 480's (hypers0 and DPA 4061's (omnis) and was able to matrix the entire 140 minute show without incident. The AKGs and SBD were run to the 680 and the 4061's were run to the M10. I hadn't yet received my PFA's from Jon so I couldn't use them for this show. I listened to this both with headphones and over speakers and the quality is just superb.
Likewise, I posted my the New Deal recording from Toronto which is a matrix of my 4061's and my friends 480's. Again, didn't have the PFA on-hand until just after the show otherwise my life would've been made easier, however, since I had the sample length for the other shows I'd already run, the sample lengths on the 4061/M10 were ahead by less than a second over 2 hours. Fixed and now up on LMA.
If I had my way, I'd run a deck that has the ability to run two sources simulatenously but since I don't do this often enough, I can't justify dropping a grand on a R-44. My friend has had NO issues with the 680 but I know many people in these parts have so I would tend to shy away from that option.