yeah you will be fine
i did 24/96 flawlessly on my picturebook w/out them, but had a few random pops/clicks w/out them with my newest lappy. so i started using them and everything is fine
they wont work with 5.0. there is something wrong with the 410 asio drivers and wavelab5.0a, i get them to work flawwlessly with any other version
you can choose more channels than just the 4, but it reccomends that you only use 4 to reduce pc load