Don't piggyback 4 ohm cabinets, you'll get 2 ohms (few amps work with 2 ohms, and some will self-destruct)
If you piggyback two 8 ohm cabinets, you get 4 ohms, which is fine if your amp is rated for it.
I've always felt safer with 8 ohm stuff and lean toward it when most else is equal.
The reason is that impedance ("ohmage") is not constant in a speaker. At some frequencies, in some placements an 8 ohm speaker can be under 5 ohms, a 4 ohm speaker can go below 2. So piggybacked 4 ohm speakers can actually approach under 1 ohm, depending on placement and frequency. It takes an amazing amp to handle that sort of load.
Hope that helps.