I would say it all depends on the software you use in post. Some software, example Samplitude, allows you to treat each channel of a stereo file separately without difficulty. Other software generally allows it but it may be a tad more involved. All multitrack software allows you to handle the four mono files in any way you want, panning, setting levels and so on. The files are in exact synch as they are recorded at the same time (regardless of if you go 2x2 or 4x1). Unless you software destroys the synch they will stay that way. I guess the R4 is as happy with either setup.
Gunnar